FeCl3·6H2O catalyzed aqueous media domino synthesis of 5-monoalkylbarbiturates: water as both reactant and solvent?
RSC Advances Pub Date: 2014-01-31 DOI: 10.1039/C4RA00093E
Abstract
A novel, simple and straightforward route to 5-monoalkylbarbiturates by FeCl3·6H2O catalyzed domino reactions of 6-aminouracils, water and α,β-unsaturated ketones, where water plays a key dual role as both reactant and solvent, is described. Significantly, all the reactions efficiently furnished exclusively 5-monoalkylbarbiturates and not pyrido[2,3-d]pyrimidines as generally produced from the reactions of 6-aminouracils and α,β-unsaturated carbonyls.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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