Highly meta-selective halogenation of 2-phenylpyridine with a ruthenium(i) catalyst?
Organic Chemistry Frontiers Pub Date: 2018-01-26 DOI: 10.1039/C7QO01133D
Abstract
We report a concise, versatile, and practical method for PhI(OCOCF3)2 mediated direct meta-C–H monohalogenation of 2-phenylpyridine and its derivatives via an Ru(I)-catalyzed reaction. The significant advantage of this transformation is the creation of a highly site-selective C–X bond by using NXS as halogenating agents under mild reaction conditions.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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