Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs?

Organic & Biomolecular Chemistry Pub Date: 2010-03-16 DOI: 10.1039/C001307B

Abstract

The GPR30 agonist probe G-1 and structural analogs were efficiently synthesized using multicomponent or stepwise Sc(III)-catalyzed aza-Diels–Alder cyclization. Optimization of solvent and reaction temperature provided enhanced endo-diastereoselectivity.

Graphical abstract: Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs
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