Functionalization of pyridyl ketones using deprotolithiation-in situ zincation?
RSC Advances Pub Date: 2016-06-28 DOI: 10.1039/C6RA11370B
Abstract
The metallation of aryl ketones was achieved by using LiTMP in the presence of ZnCl2·TMEDA, as evidenced by subsequent interception with iodine or by a palladium-catalysed cross-coupling reaction. One of the synthesized iodo ketones has been further elaborated to reach derivatives of biological interest.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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