Highly effective copper-mediated gem-difluoromethylenation of arylboronic acids?
Chemical Communications Pub Date: 2014-06-03 DOI: 10.1039/C4CC03321C
Abstract
A copper-mediated gem-difluoromethylenation of aryl, heteroaryl and vinyl boronic acids with bromodifluoromethylated oxazole or thiazole derivatives has been developed. This novel reaction showed an excellent functional group tolerance and wide substrate scope, providing facile access to practical application in drug discovery and development.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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