High-performance liquid chromatographic assay of temocillin and epimerisation of its diastereoisomers
ANALYSTANALYST Pub Date: DOI: 10.1039/AN9840901209
Abstract
Assay of temocillin by a high-performance liquid chromatographic method that resolves the diastereoisomers is described and potential difficulties in the chromatographic quantitation of a compound that contains two isomers are discussed. Nuclear magnetic resonance spectra of the separate diastereoisomers were used to assign the R and S configuration of the side-chain to the first and second eluting isomers, respectively. Epimerisation of the isomers was investigated and equilibration half-lives and the isomer composition at equilibrium were determined.
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Journal Name：ANALYSTANALYST
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CAS no.: 89640-58-4
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