Facile synthesis of 4-acetoxyindoles via PhI(OAc)2-mediated dearomatization of 2-alkynylanilines?
Organic Chemistry Frontiers Pub Date: 2021-04-08 DOI: 10.1039/D1QO00358E
Abstract
A process for rapid synthesis of 4-acetoxyindoles from readily available 2-alkynylanilines was reported. The process involves an oxidative dearomatization and subsequent cascade nucleophilic addition/cyclization/aromatization. A range of functional groups can be tolerated in this process. The formed 4-acetoxyindoles are versatile precursors to a variety of C4-functionalized indoles through simple conversions.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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