Facile synthesis of 2,2′-dinitrosubstituted biaryls through Cu-catalyzed ligand-free decarboxylative homocoupling of ortho-nitrobenzoic acids?

RSC Advances Pub Date: 2015-06-02 DOI: 10.1039/C5RA07771K

Abstract

A novel waste-free Cu-catalyzed decarboxylative homocoupling of ortho-nitrobenzoic acids has been developed, and diverse substituents on the phenyl core of ortho-nitrobenzoic acid are compatible with the transformation. This method provides a practical alternative to synthesize valuable 2,2′-dinitrosubstituted biaryls from cheap and readily available ortho-nitrobenzoic acids.

Graphical abstract: Facile synthesis of 2,2′-dinitrosubstituted biaryls through Cu-catalyzed ligand-free decarboxylative homocoupling of ortho-nitrobenzoic acids
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