Facile one-pot synthesis of unsymmetrical ureas, carbamates, and thiocarbamates from Cbz-protected amines?
Organic & Biomolecular Chemistry Pub Date: 2016-07-05 DOI: 10.1039/C6OB01290F
Abstract
A novel one-pot synthesis of unsymmetrical ureas, carbamates and thiocarbamates from Cbz-protected amines has been developed. In the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, isocyanates are generated in situ, which facilitate rapid reaction with amines, alcohols, and thiols to afford the corresponding ureas, carbamates and thiocarbamates in high yields.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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