A mild electroassisted synthesis of (hetero)arylphosphonates?
Organic & Biomolecular Chemistry Pub Date: 2018-06-01 DOI: 10.1039/C8OB00500A
Abstract
The electrochemically-assisted synthesis of (hetero)arylphosphonates from (hetero)aryl halides and dimethyl phosphite is described. Very mild and simple conditions are employed as the cross-coupling is carried out in galvanostatic mode, in an undivided cell at room temperature, using NiBr2bpy as the easily available pre-catalyst and acetonitrile as the solvent. In addition, both aryl bromides and iodides can be used as well, providing the corresponding (hetero)arylphosphonates in generally good yields. A mechanism involving the in situ generation of a Ni ate complex is proposed.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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