A microwave-assisted multicomponent synthesis of substituted 3,4-dihydroquinazolinones?
Organic & Biomolecular Chemistry Pub Date: 2014-12-05 DOI: 10.1039/C4OB02417F
Abstract
A microwave-assisted, multicomponent protocol for the synthesis of substituted 3,4-dihydroquinazolinones via a novel cascade imine/cyclization/aza-Henry reaction sequence is reported. Starting from o-formyl carbamates, a series of structurally diverse 3,4-dihydroquinazolinones was synthesized via a cyclic iminium ion intermediate in moderate to excellent yields. Notably, the reaction is fast, flexible, simple to perform and tolerates a variety of functional groups.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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