Ethynylbenzenoid metabolites of Antrodia camphorata: synthesis and inhibition of TNF expression?
Organic & Biomolecular Chemistry Pub Date: 2013-12-19 DOI: 10.1039/C3OB42333F
Abstract
An improved synthesis of the anti-inflammatory natural product antrocamphin A (2), involving a key Castro–Stephens reaction, is presented, along with the first total synthesis of its congener antrocamphin B (3). Approaches towards the more complex co-metabolite antrodioxolanone (4) were unsuccessful, but a samarium diiodide-mediated pinacol coupling of antrocamphin B did provide the chiral epimers (51). Antrocamphin A (2) inhibits Tumour Necrosis Factor (TNF) reporter gene expression, but its development as an anti-inflammatory agent may be limited by cytotoxicity.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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