Enone-promoted decarboxylation of trans-4-hydroxy-l-proline in flow: a side-by-side comparison to batch?
Reaction Chemistry & Engineering Pub Date: 2021-01-07 DOI: 10.1039/D0RE00442A
Abstract
An efficient and scalable enone-promoted method for the decarboxylation of trans-4-hydroxy-proline has been developed in flow to provide access to (R)-pyrrolidin-3-ol hydrochloride using biomass-derived isophorone. The advantages of deploying flow in this setting were reinforced by direct comparsion to batch. This method lays a foundation for fossil fuel and ammonia free alternative access to amines on scales relevant to manufacturing.
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Journal Name：Reaction Chemistry & Engineering
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CAS no.: 89640-58-4
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