Gold(i)-catalyzed enantioselective bromocyclization reactions of allenes?

Chemical Science Pub Date: 2013-07-05 DOI: 10.1039/C3SC50811K

Abstract

The enantioselective bromocyclization of allenes is accomplished through the use of a chiral dinuclear gold complex and/or chiral phosphate anions in the presence of an N-bromolactam as an electrophilic bromine source. This method provides access to heterocyclic vinyl bromides with an allylic stereocenter in excellent yield and enantioselectivity. These enantioenriched vinyl bromides may serve as a handle for further derivatization via cross-coupling reactions.

Graphical abstract: Gold(i)-catalyzed enantioselective bromocyclization reactions of allenes
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