Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles?

Chemical Communications Pub Date: 2009-05-27 DOI: 10.1039/B905068J

Abstract

We report the generation of novel glycosylated indolocarbazoles by combinatorial biosynthesis, and the identification of two novel potent and selective compounds inhibitors of JAK2 and Ikkb kinases.

Graphical abstract: Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles
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