First asymmetric total synthesis of aspergillide D?
Organic & Biomolecular Chemistry Pub Date: 2017-01-24 DOI: 10.1039/C6OB02435A
Abstract
The first asymmetric total synthesis of a 16-membered macrolide, aspergillide D, is described. The chiral centers of the acid are derived from D-ribose and the alcohol subunit from 1,8-octane diol through Sharpless kinetic resolution, respectively. The other key reactions include Yamaguchi esterification, ring-closing metathesis reaction, and Shiina macrolactonization to construct the fully functionalized macrocycle.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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