General and efficient method for direct N-monomethylation of aromatic primary amines with methanol?

RSC Advances Pub Date: 2012-07-26 DOI: 10.1039/C2RA21487C

Abstract

The direct N-monomethylation of aromatic primary amines, including arylamines, arylsulfonamides and amino-azoles, using methanol as a methylating agent has been accomplished in the presence of a [Cp*IrCl2]2/NaOH system. From both synthetic and environmental points of view, the reaction is highly attractive because of low catalyst loading, broad substrate scope and excellent selectivities.

Graphical abstract: General and efficient method for direct N-monomethylation of aromatic primary amines with methanol
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