Gallium-catalyzed reductive lactonization of γ-keto acids with a hydrosilane?

RSC Advances Pub Date: 2016-08-22 DOI: 10.1039/C6RA19286F

Abstract

Described herein is the GaCl3-catalyzed lactonization of γ-keto carboxylic acids in the presence of PhSiH3 leading to the direct preparation of γ-lactone derivatives. This reducing system showed a relatively wide functional group tolerance.

Graphical abstract: Gallium-catalyzed reductive lactonization of γ-keto acids with a hydrosilane
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