Gelatin-functionalized mesoporous silica nanoparticles with sustained release properties for intracameral pharmacotherapy of glaucoma?
Journal of Materials Chemistry B Pub Date: 2017-08-14 DOI: 10.1039/C7TB01217A
Abstract
Herein, pilocarpine-loaded gelatin-covered mesoporous silica nanoparticles (denoted as p/GM) were intracamerally administrated into the anterior chamber for the reduction of intraocular pressure (IOP). The in vitro release profile shows that p/GM demostrates a high release percentage (50%) with a long-lasting release profile (36 days). The in vivo studies showed the maintenance of IOP in eye with ocular hypertension for 21 days.
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Journal Name：Journal of Materials Chemistry B
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CAS no.: 89640-58-4
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