Enhanced acid stability of a reduced nicotinamide adenine dinucleotide (NADH) analogue

Chemical Communications Pub Date: 2001-10-03 DOI: 10.1039/B107634P

Abstract

A methyl substituent at C-5 of the nicotinamide ring is found to confer increased acid stability in a reduced nicotinamide model (5–20 fold) and in a reduced dinucleotide coenzyme (2–3 fold), while retaining reactivity towards hydride transfer.

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