A mild two-step propargylation of aromatic bioactive small molecules?
Organic & Biomolecular Chemistry Pub Date: 2017-08-08 DOI: 10.1039/C7OB01587A
Abstract
A two-step method for introducing a propargyl group in aromatic bioactive small molecules has been developed. This method features propargylation of aromatic groups using a cationic propargyl hexacarbonyl complex in the presence of cesium carbonate, and decomplexation of the resultant cobalt complexes using 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate. These reactions proceed under mild conditions, and thus are applicable for acid- and/or oxidant-sensitive aromatic bioactive small molecules.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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