Enantioselective synthesis of an axially chiral 1,7-naphthyridine-6-carboxamide derivative having potent antagonist activity at the NK1 receptor
Chemical Communications Pub Date: 1900-01-01 DOI: 10.1039/A805333B
Abstract
A new and highly potent NK1 antagonist, (aR,9R)-3 [(aR,9R)-7-[3,5-bis(trifluoromethyl)benzyl]-8,9,10,11-tetrahydro-9-methyl-5-(4-methylphenyl)-7H-[1,4]diazocino[2,1-g][1,7]naphthyridine-6,13-dione], was atropdiastereoselectively synthesized in good yield by cyclization of the chiral intermediate 6b.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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