Enantioselective separation of chiral ofloxacin using functional Cu(ii)-coordinated G-rich oligonucleotides?

RSC Advances Pub Date: 2013-10-03 DOI: 10.1039/C3RA43251C

Abstract

The DNA-based selector for discriminating chiral ofloxacin with high enantioselectivity and affinity is constructed through Cu(II)-coordination with G-rich duplex containing successive guanines. Using this chiral selector, R- and S-ofloxacin can be directly enriched from the racemate, with the enantiomeric excess of 85% (R) and 78% (S) individually by three operational stages.

Graphical abstract: Enantioselective separation of chiral ofloxacin using functional Cu(ii)-coordinated G-rich oligonucleotides
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