Enantioselective biocatalytic formal α-amination of hexanoic acid to l-norleucine?
Organic & Biomolecular Chemistry Pub Date: 2018-10-05 DOI: 10.1039/C8OB02212G
Abstract
A three-step one-pot biocatalytic cascade was designed for the enantioselective formal α-amination of hexanoic acid to L-norleucine. Regioselective hydroxylation by P450CLA peroxygenase to 2-hydroxyhexanoic acid was followed by oxidation to the ketoacid by two stereocomplementary dehydrogenases. Combination with final stereoselective reductive amination by amino acid dehydrogenase furnished L-norleucine in >97% ee.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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