Facile synthesis of 2-(2-aminobenzoyl)benzoic acids via a base-promoted aerobic cascade reaction?

Organic Chemistry Frontiers Pub Date: 2019-03-05 DOI: 10.1039/C9QO00101H

Abstract

A novel strategy for the regiospecific synthesis of 2-(2-aminobenzoyl)benzoic acids via a base-promoted aerobic cascade reaction has been exploited. The protocol led to a wide panel of 2-(2-aminobenzoyl)benzoic acids with a broad substrate scope in an atom-economical manner. Six new bonds were sequentially formed in this one-pot procedure.

Graphical abstract: Facile synthesis of 2-(2-aminobenzoyl)benzoic acids via a base-promoted aerobic cascade reaction
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