A metal-free method for the facile synthesis of indanones via the intramolecular hydroacylation of 2-vinylbenzaldehyde?
Green Chemistry Pub Date: 2020-12-24 DOI: 10.1039/D0GC03572F
Abstract
A facile method for the synthesis of indanones was developed under metal- and additive-free conditions, wherein L-proline served as an efficient and environmentally benign catalyst. Compared with previously synthesized indanones, synthesis by the transition-metal-catalyzed intramolecular hydroacylation of 2-vinylbenzaldehyde provided a more green synthetic pathway to indanone scaffolds with good to excellent yields. More importantly, it could be used to synthsize the anti-AD drug donepezil.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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