Fluorine gas for life science syntheses: green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters?
Green Chemistry Pub Date: 2015-03-17 DOI: 10.1039/C5GC00402K
Abstract
Optimisation and real time reaction monitoring of the synthesis of 2-fluoromalonate esters by direct fluorination using fluorine gas is reported. An assessment of green metrics including atom economy and process mass intensity factors, demonstrates that the one-step selective direct fluorination process compares very favourably with established multistep processes for the synthesis of fluoromalonates.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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