Formal total synthesis of calothrixin B and its N-benzyl analogues?

RSC Advances Pub Date: 2015-10-07 DOI: 10.1039/C5RA18120H

Abstract

A formal total synthesis of calothrixin B and its N-benzyl analogues has been accomplished from (2-chlorophenyl)boronic acid, 8-bromophenanthridine-7,10-dione and benzylamines. The synthesis involves Suzuki cross-coupling and copper-catalyzed domino reactions to generate N-benzylcalothrixins in good to moderate yields.

Graphical abstract: Formal total synthesis of calothrixin B and its N-benzyl analogues
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