Folding and self-assembly of aromatic and aliphatic urea oligomers: Towards connecting structure and function

Organic & Biomolecular Chemistry Pub Date: 2010-05-26 DOI: 10.1039/C001090A

Abstract

Folding and self-assembly of biomacromolecules has inspired the development of discrete, non-natural oligomers that fold and/or self-assemble in a controlled manner. Though aromatic and aliphatic oligoamides remain unmatched for structural diversity and synthetic versatility, oligomers based on amide bond surrogates, such as urea backbones, also demonstrated a propensity for folding and self-assembly. In this Perspective, we review the advances in the design of oligomeric aromatic and aliphatic urea sequences (essentially N,N′-linked) that fold and/or self-assemble. Whenever applicable, the relationship between structure and function will be highlighted.

Graphical abstract: Folding and self-assembly of aromatic and aliphatic urea oligomers: Towards connecting structure and function
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