Flexible synthesis of polyfunctionalised 3-fluoropyrroles?

Organic & Biomolecular Chemistry Pub Date: 2015-11-05 DOI: 10.1039/C5OB02155C

Abstract

An efficient and selective approach for the synthesis of polyfunctionalised 3-fluoropyrroles has been developed starting from commercial aldehydes. The methodology is concise, efficient and allows for the modular and systematic assembly of polysubstituted 3-fluoropyrroles. This synthesis provides an alternative and highly convergent strategy for the generation of these chemically and biologically important units.

Graphical abstract: Flexible synthesis of polyfunctionalised 3-fluoropyrroles
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