Efficient, mild and completely regioselective synthesis of substituted pyridines?

Chemical Communications Pub Date: 2010-03-16 DOI: 10.1039/C000748J

Abstract

Addition of Grignard reagents to pyridine N-oxides in THF at low temperature (?78 to ?20 °C) and treatment with TFAA provides an efficient general procedure for synthesis of substituted pyridines. The method is compatible with a range of functional groups such as esters, halogens and nitriles.

Graphical abstract: Efficient, mild and completely regioselective synthesis of substituted pyridines
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