Efficient synthesis of isoquinolines and pyridines via copper(i)-catalyzed multi-component reaction?
RSC Advances Pub Date: 2014-01-31 DOI: 10.1039/C3RA46722H
Abstract
A wide range of 3-substituted isoquinolines, steroidal pyridines, 5,6-dihydrobenzo[f]isoquinolines and 1,6-naphthyridine were synthesized in good yield via a ligand-free copper-catalyzed three-component reaction of β-halovinyl/aryl aldehyde, aromatic/aliphatic terminal alkyne and tert-butylamine/benzamidine in DMF under microwave irradiation. A catalyst-free reaction of ortho-alkynyl aryl/vinyl aldehydes with benzamidine under microwave irradiation also provided the 3-substituted isoquinoline and substituted pyridine derivatives in excellent yield.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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