Expedient Diels–Alder cycloadditions with ortho-quinodimethanes in a high temperature/pressure flow reactor?
Reaction Chemistry & Engineering Pub Date: 2017-05-23 DOI: 10.1039/C7RE00058H
Abstract
We describe herein Diels–Alder cycloadditions enabled by the efficient ring-opening of benzocyclobutenes and benzothiophene-2,2-dioxides using a high temperature/pressure flow reactor. The resultant ortho-quinodimethanes were generated and subsequently reacted with a wide range of dienophiles to provide complex heterocyclic ring systems. The use of flow technology allowed these reactions to be completed within minutes using conventional, readily removed solvents.
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Journal Name：Reaction Chemistry & Engineering
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CAS no.: 89640-58-4
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