A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO)?

Dalton Transactions Pub Date: 2013-05-21 DOI: 10.1039/C3DT51152A

Abstract

A stable Re complex containing an imidazopyridine ligand with a high affinity for TSPO has been synthesized as a model for new 99mTc or 188/186Re-based radiopharmaceuticals to be used in SPECT diagnosis or in therapy, respectively. The new complex fac-[ReBr(CO)3(TZ6)], structurally characterized, showed high affinity (nanomolar concentration) for the target protein.

Graphical abstract: A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO)
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