A mild and facile synthesis of polyfunctionalized pyridines: merging three-component cyclization and aerobic oxidation by amine/metal catalysts?
Organic & Biomolecular Chemistry Pub Date: 2015-04-28 DOI: 10.1039/C5OB00630A
Abstract
A mild and facile synthesis of polyfunctionalized pyridines from NH4OAc, β,γ-unsaturated α-ketoesters, and ketones/aldehydes has been reported through tandem three-component cyclization and aerobic oxidation using the combination of amine and metal catalysts. The synthetic value of the developed methodology was demonstrated by a gram-scale reaction and a wide range of substrates including naturally occurring citronellal.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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