Facile synthesis of 3-(aminomethyl)isoquinolines by copper-catalysed domino four-component coupling and cyclisation?

Chemical Communications Pub Date: 2008-01-04 DOI: 10.1039/B718201E

Abstract

Copper(I)-catalysed domino four-component coupling–cyclisation using 2-ethynylbenzaldehydes, paraformaldehyde, secondary amine, and t-BuNH2 in DMF leads to direct and efficient formation of 3-(aminomethyl)isoquinolines in good to high yields.

Graphical abstract: Facile synthesis of 3-(aminomethyl)isoquinolines by copper-catalysed domino four-component coupling and cyclisation
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