Facile synthesis of nonsymmetrical heteroaryl-substituted triarylmethanes via the FeCl3·6H2O-catalyzed two-step Friedel–Crafts-type reaction?
Organic & Biomolecular Chemistry Pub Date: 2016-08-16 DOI: 10.1039/C6OB01638C
Abstract
The FeCl3·6H2O-catalyzed three-component aza-Friedel–Crafts reaction of aromatic/heteroaromatic compounds, aromatic aldehydes and tert-butyl carbamate was reported. The subsequent Friedel–Crafts-type alkylation of the resulting tert-butyl diarylmethyl carbamate with heteroaromatic compounds under “open-flask” at room temperature was also performed. The two-step reaction was especially useful for the synthesis of functionalized nonsymmetrical heteroaryl-substituted triarylmethanes in good yields under an air atmosphere at room temperature.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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