Facile amidinations of 2-aminophenylboronic acid promoted by boronate ester formation?
Organic & Biomolecular Chemistry Pub Date: 2019-01-03 DOI: 10.1039/C8OB02696C
Abstract
Amidine synthesis by amine addition to nitriles normally requires high temperatures or harsh catalysts. Here, we report that boronate esters can facilitate amidination of proximal amines with moderate heating. With amidines present in a number of drugs and the synthetic handle provided by the boron, this chemistry should find useful applications.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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