Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: key precursors to potent c-Met inhibitors?

Organic & Biomolecular Chemistry Pub Date: 2011-07-01 DOI: 10.1039/C1OB05830D

Abstract

An effective one-pot synthesis of quinolines bearing diverse C3-piperazinyl functions was developed by using a modified Friedl?nder's protocol. The method not only enables the synthesis of our early reported c-Met inhibitor on a large scale, but also provides a way to generate novel multi-substituted quinolines for further structure–activity relationship (SAR) study.

Graphical abstract: Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: key precursors to potent c-Met inhibitors
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