A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives?

Green Chemistry Pub Date: 2016-05-31 DOI: 10.1039/C6GC01125J

Abstract

A highly efficient and green method has been developed for the rapid preparation of highly functionalized isoxazolopyridin-3-amine derivatives in excellent yields. This process has a broad substrate scope, is operationally simple, and generally requires no chromatographic purification. In addition, the process is scalable and significantly greener than current alternatives with a PMI of 18 and water as the reaction solvent.

Graphical abstract: A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives
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