Efficient synthesis of the anticancer β-elemene and other bioactive elemanes from sustainable germacrone?

Organic & Biomolecular Chemistry Pub Date: 2010-12-24 DOI: 10.1039/C0OB00467G

Abstract

Highly efficient preparations of anticancer β-elemene and other bioactive elemanes were carried out using the natural product germacrone as a renewable starting material. The syntheses were achieved in only 3–5 steps with excellent overall yields (43–54%). An enantioselective approach to these molecules is also described

Graphical abstract: Efficient synthesis of the anticancer β-elemene and other bioactive elemanes from sustainable germacrone
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