Enantioselective synthesis of levomilnacipran??

Chemical Communications Pub Date: 2012-06-22 DOI: 10.1039/C2CC33743F

Abstract

A novel approach for the asymmetric synthesis of the active (1S,2R)-enantiomer of the antidepressant milnacipran is reported. The two stereogenic centers borne by the cyclopropane ring were sequentially installed starting from phenylacetic acid.

Graphical abstract: Enantioselective synthesis of levomilnacipran
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