Efficient Cu-catalyzed intramolecular O-arylation for synthesis of benzoxazoles in water?

RSC Advances Pub Date: 2020-04-07 DOI: 10.1039/D0RA00570C

Abstract

An efficient method was developed for synthesis of benzoxazoles by Cu-catalyzed intramolecular O-arylation of o-halobenzanilides in water. This strategy provides several advantages, such as high yields, water as a green solvent and functional groups tolerance.

Graphical abstract: Efficient Cu-catalyzed intramolecular O-arylation for synthesis of benzoxazoles in water
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