Efficient biosynthesis of enantiopure tolvaptan by utilizing alcohol dehydrogenase-catalyzed enantioselective reduction?
Green Chemistry Pub Date: 2018-02-13 DOI: 10.1039/C7GC03679E
Abstract
Using whole cells of Escherichia coli co-expressing alcohol dehydrogenase (PsADH) and formate dehydrogenase (CpFDH) in a biphasic aqueous–soybean oil system is shown to be an efficient method for the biosynthesis of enantiopure tolvaptan. In this system, (S)-tolvaptan with an optical purity of 99.5% and a bioconversion efficiency of 86.1% was achieved.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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