Enantioselective conjugate hydrosilylation of α,β-unsaturated ketones?

RSC Advances Pub Date: 2019-04-12 DOI: 10.1039/C9RA01180C

Abstract

Enantioselective conjugate hydrosilylation of β,β-disubstituted α,β-unsaturated ketones was realized. In the presence of a chiral picolinamide–sulfonate Lewis base catalyst, the reactions provided various chiral ketones bearing a chiral center at the β-position in up to quantitative yields with moderate enantioselectivities.

Graphical abstract: Enantioselective conjugate hydrosilylation of α,β-unsaturated ketones
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