Efficient and scalable Pd-catalyzed double aminocarbonylations under atmospheric pressure at low catalyst loadings??
Organic Chemistry Frontiers Pub Date: 2014-10-22 DOI: 10.1039/C4QO00253A
Abstract
By using a robust acenaphthoimidazolylidene palladium complex (Pd-NHC 1), a scalable approach to access a variety of chiral, pharmaceutical and structurally intriguing N-substituted phthalimides via double aminocarbonylations has been established under atmospheric carbon monoxide pressure at catalyst loadings as low as 0.05 mol%. In addition, the fluorescent properties of the selected N-substituted phthalimide products were also characterized. In comparison with well-known fluorescent molecules, some of them exhibited enhanced violet emission, especially for the ester analogue of Alrestatin, which further confirmed the applicability of the protocol.
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Journal Name：Organic Chemistry Frontiers
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