Electrophilic α-cyanation of 1,3-dicarbonyl compounds?
RSC Advances Pub Date: 2013-04-19 DOI: 10.1039/C3RA41376D
Abstract
Electrophilic α-cyanation of activated methylene compounds was achieved under mild basic conditions using commercially available TsCN as a CN+ equivalent. A series of 1,3-dicarbonyl compounds, both cyclic and acyclic, were found to be suitable substrates for this transformation. Subjecting 1,1,1-trifluoro-1,3-dicarbonyl compounds to a modified procedure resulted in the formation of α-cyano
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Journal Name：RSC Advances
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