Efficient and selective catalytic oxidative cleavage of α-hydroxy ketones using vanadium-based HPA and dioxygen

Chemical Communications Pub Date: 2001-10-05 DOI: 10.1039/B106969A

Abstract

The combination of H3 + n[PMo12 ? nVnO 40]·aq (HPA-n, n = 3) and dioxygen provides a clean and regioselective reagent for the homolytic cleavage of various representative α-hydroxy ketones (primary to tertiary) and turns out to be as efficient for the catalytic ring opening of chiral natural products.

Graphical abstract: Efficient and selective catalytic oxidative cleavage of α-hydroxy ketones using vanadium-based HPA and dioxygen
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