A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides?
Organic & Biomolecular Chemistry Pub Date: 2015-09-09 DOI: 10.1039/C5OB01706H
Abstract
D-Glucosamine derivatives bearing latent O4 functionality provide modified H/HS-type disaccharide donors for a final stage capping approach enabling introduction of conjugation-suitable, non-reducing terminal functionality to biologically important glycosaminoglycan oligosaccharides. Application to the synthesis of the first O4-terminus modified synthetic LMWH decasaccharide and an HS-like dodecasaccharide is reported.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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