Effect of the steric demand and hydrogen bonding capability of additives on the crystal polymorphism of sulfathiazole

CrystEngComm Pub Date: 2006-03-23 DOI: 10.1039/B516716G

Abstract

The N-acylsulfathiazole deriviatives 2, 3 and 4, the polymeric N-acylsulfathiazole 6 and the phenolic sulfathiazole analogue 7 were prepared and were found to promote crystallization of form I sulfathiazole from water with inhibition of forms II, III and IV; suggesting that the mode of action of the additives may involve other factors in addition to compatibility with the hydrogen-bonding structure of the various forms.

Graphical abstract: Effect of the steric demand and hydrogen bonding capability of additives on the crystal polymorphism of sulfathiazole
Recommended Literature